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A decision tool to assist the control of Human African Trypanosomiasis
HAT-trick is designed to help planners develop cost-effective strategies for controlling sleeping sickness using various methods of tsetse control. Modelling is conducted at three successive levels.
First, the Basic Level covers fundamental aspects of tsetse and trypanosome biology that apply in any situation. The users can either define their own values for each of the parameters or select a species of tsetse (e.g., G. morsitans, G. pallidipes, G. palpalis, G. fuscipes) and trypanosome (i.e., T. b. rhodesiense or T. b. gambiense) with a pre-defined set of parameters based on published data.
Second, the Map Level combines outputs from the Basic level with inputs specific to a particular operational area. The user specifies the landcover and the distribution of humans and wild hosts across a two-dimensional landscape of 625 to 40,000 square kilometres. The programme then combines these data with the Basic level outputs to generate a prediction of:
The programme produces maps and tables summarising the predicted distribution of tsetse and sleeping sickness across the landscape.
Third, the Control Level simulates the impact of tsetse control. The user has a range of tsetse control methods available:
These techniques can be either used alone or in any spatial and temporal combination specified by the user. HAT-trick provides a dynamic view of tsetse and trypanosomiasis as the control operation progresses and at the conclusion of the operation, the programme produces a series of maps, graphs and tables summarising changes in
For a simple overview of the programme and its outputs, have a look at this poster.
The programme has been written to operate on Microsoft Office Excel (version 2003) but can also be operated using Excel 2007 and 2010.
To run HAT-trick, the macro security level of Excel 2003 must not be set to 'high'. So, before opening begin.xls, please set the 'Macro security' in the 'Tools' menu to 'medium'. For later versions of Excel (2007 and 2010), you need to change the macro settings in the Trust Centre to 'Enable all macros' and change the save option to 'Excel 97-2003 Workbook' format.
The HAT-trick Development Team
Glyn Vale and John Hargrove from the South African Centre for Epidemiological Modelling and Analysis (SACEMA), University of Stellenbosch, South Africa;
Philippe Solano and Fabrice Courtin from the institut de recherche pour le développement (IRD), France;
Dramane Kaba from the Institut Pierre Richet, Côte d'Ivoire;
Jean-Baptiste Rayaisse from the centre international de recherche-développement sur l'elevage en zone subhumide (CIRDES), Bukina Faso;
Clement Mangwiro from the Bindura University of Science Education, Zimbabwe;
Themba Mzilahowa from the University of Malawi College of Medicine;
Andrew Chamisa from the Tsetse and Trypanosomiasis Control Department, Zimbabwe;
Atway Msangi and Mechtilda Byamungu from the Tsetse and Trypanosomiasis Research Institute, Tanzania;
Mike Lehane and Ian Hastings from the Liverpool School of Tropical Medicine, UK;
Ian Maudlin from the University of Edinbugh, UK;